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  WRN protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
WRN
Werner syndrome, RecQ helicase-like; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA- helicase activity. May be involved in the control of genomic stability (By similarity) (1432 aa)
(Homo sapiens)
Predicted Functional Partners:
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6; Single stranded DNA-dep [...] (609 aa)
      0.999
FEN1
flap structure-specific endonuclease 1; Endonuclease that cleaves the 5'-overhanging flap struc [...] (380 aa)
      0.999
XRCC5
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rej [...] (732 aa)
      0.999
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
      0.998
RPA1
replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA met [...] (616 aa)
      0.993
TERF2
telomeric repeat binding factor 2; Binds the telomeric double-stranded TTAGGG repeat. Protects [...] (500 aa)
     0.993
POLB
polymerase (DNA directed), beta; Repair polymerase. Conducts "gap-filling" DNA synthesis in a s [...] (335 aa)
      0.993
HYRC
protein kinase, DNA-activated, catalytic polypeptide; Serine/threonine-protein kinase that acts [...] (4127 aa)
      0.992
MRE11A
MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which p [...] (708 aa)
       0.990
PCNA
proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)
      0.986
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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