WRN protein (Homo sapiens) - STRING interaction network

WRN protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	WRN	Werner syndrome, RecQ helicase-like; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA- helicase activity. May be involved in the control of genomic stability (By similarity) (1432 aa)
		(Homo sapiens)
Predicted Functional Partners:
	XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6; Single stranded DNA-dep [...] (609 aa)	•		•	0.999
	FEN1	flap structure-specific endonuclease 1; Endonuclease that cleaves the 5'-overhanging flap struc [...] (380 aa)	•		•	0.999
	XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rej [...] (732 aa)	•		•	0.999
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)	•		•	0.998
	RPA1	replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA met [...] (616 aa)	•		•	0.993
	TERF2	telomeric repeat binding factor 2; Binds the telomeric double-stranded TTAGGG repeat. Protects [...] (500 aa)	•	•	•	0.993
	POLB	polymerase (DNA directed), beta; Repair polymerase. Conducts "gap-filling" DNA synthesis in a s [...] (335 aa)	•		•	0.993
	HYRC	protein kinase, DNA-activated, catalytic polypeptide; Serine/threonine-protein kinase that acts [...] (4127 aa)	•		•	0.992
	MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which p [...] (708 aa)			•	0.990
	PCNA	proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delt [...] (261 aa)	•		•	0.986

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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