version_number_image
  SPINK1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
SPINK1
serine peptidase inhibitor, Kazal type 1; This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas (79 aa)
(Homo sapiens)
Predicted Functional Partners:
PRSS1
protease, serine, 2 (trypsin 2); Has activity against the synthetic substrates Boc-Phe- Ser-Arg [...] (247 aa)
       0.993
PRSS3
protease, serine, 3 (304 aa)
       0.968
CTRC
chymotrypsin C (caldecrin); Has chymotrypsin-type protease activity and hypocalcemic activity (268 aa)
      0.951
TMPRSS15
protease, serine, 7 (enterokinase); Responsible for initiating activation of pancreatic proteol [...] (1019 aa)
      0.936
ELANE
elastase, neutrophil expressed; Modifies the functions of natural killer cells, monocytes and g [...] (267 aa)
       0.932
PGC
progastricsin (pepsinogen C); Hydrolyzes a variety of proteins (388 aa)
       0.931
TRYX3
Trypsin-X3 Precursor (EC 3.4.21.4) (241 aa)
       0.920
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member [...] (1480 aa)
       0.853
EGFR
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)
       0.823
CCK
cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancr [...] (115 aa)
       0.806
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (8%)
Permalink