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  PF4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PF4
platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form (101 aa)
(Homo sapiens)
Predicted Functional Partners:
CXCR3
chemokine (C-X-C motif) receptor 3; Receptor for CXCL9, CXCL10 and CXCL11 and mediates the prol [...] (415 aa)
     0.999
PROC
protein C (inactivator of coagulation factors Va and VIIIa); Protein C is a vitamin K-dependent [...] (461 aa)
     0.997
CXCR2
chemokine (C-X-C motif) receptor 2; Receptor for interleukin-8 which is a powerful neutrophil c [...] (360 aa)
      0.994
CXCL11
chemokine (C-X-C motif) ligand 11; Chemotactic for interleukin-activated T-cells but not unstim [...] (94 aa)
      0.992
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); LA-PF4 stimulates DNA synthesis, [...] (128 aa)
    0.985
THBD
thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1-1 stoichi [...] (575 aa)
      0.981
FN1
fibronectin 1; Fibronectins bind cell surfaces and various compounds including collagen, fibrin [...] (2477 aa)
      0.980
SRGN
serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of va [...] (158 aa)
     0.979
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; [...] (402 aa)
      0.979
F8
coagulation factor VIII, procoagulant component; Factor VIII, along with calcium and phospholip [...] (2351 aa)
      0.976
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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