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  BTBD12 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
BTBD12
BTB (POZ) domain containing 12; Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA c [...] (1834 aa)
(Homo sapiens)
Predicted Functional Partners:
GIYD1
GIY-YIG domain containing 1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease [...] (275 aa)
     0.990
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes [...] (323 aa)
      0.989
EME1
essential meiotic endonuclease 1 homolog 1 (S. pombe); Interacts with MUS81 to form a DNA struc [...] (570 aa)
      0.976
MUS81
MUS81 endonuclease homolog (S. cerevisiae); Interacts with EME1 and EME2 to form a DNA structur [...] (551 aa)
      0.965
ERCC4
excision repair cross-complementing rodent repair deficiency, complementation group 4; Structur [...] (916 aa)
      0.957
GEN1
Gen homolog 1, endonuclease (Drosophila); Endonuclease which cleaves flap structures at the jun [...] (908 aa)
       0.948
C20orf94
UPF0492 protein C20orf94 (408 aa)
      0.941
LOX
lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine [...] (417 aa)
       0.848
TERF2
telomeric repeat binding factor 2; Binds the telomeric double-stranded TTAGGG repeat. Protects [...] (500 aa)
      0.841
MSH3
mutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). H [...] (1137 aa)
      0.840
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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