BTBD12 protein (Homo sapiens) - STRING interaction network

BTBD12 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	BTBD12	BTB (POZ) domain containing 12; Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA c [...] (1834 aa)
		(Homo sapiens)
Predicted Functional Partners:
	GIYD1	GIY-YIG domain containing 1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease [...] (275 aa)	•	•	•	0.990
	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes [...] (323 aa)	•		•	0.989
	EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe); Interacts with MUS81 to form a DNA struc [...] (570 aa)	•		•	0.976
	MUS81	MUS81 endonuclease homolog (S. cerevisiae); Interacts with EME1 and EME2 to form a DNA structur [...] (551 aa)	•		•	0.965
	ERCC4	excision repair cross-complementing rodent repair deficiency, complementation group 4; Structur [...] (916 aa)	•		•	0.957
	GEN1	Gen homolog 1, endonuclease (Drosophila); Endonuclease which cleaves flap structures at the jun [...] (908 aa)			•	0.948
	C20orf94	UPF0492 protein C20orf94 (408 aa)	•		•	0.941
	LOX	lysyl oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine [...] (417 aa)			•	0.848
	TERF2	telomeric repeat binding factor 2; Binds the telomeric double-stranded TTAGGG repeat. Protects [...] (500 aa)	•		•	0.841
	MSH3	mutS homolog 3 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). H [...] (1137 aa)	•		•	0.840

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Co-expression Experiments Databases Textmining

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