ACE protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

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angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (1306 aa)
(Homo sapiens)
Predicted Functional Partners:
angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the ren [...] (485 aa)
angiotensin II receptor, type 1; Receptor for angiotensin II. Mediates its action by associatio [...] (359 aa)
renin; Renin is a highly specific endopeptidase, whose only known function is to generate angio [...] (406 aa)
bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate [...] (391 aa)
angiotensin II receptor, type 2; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit [...] (363 aa)
DCP2 decapping enzyme homolog (S. cerevisiae); Necessary for the degradation of mRNAs, both in [...] (420 aa)
nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) which is implicated in v [...] (1203 aa)
kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an impor [...] (644 aa)
natriuretic peptide precursor A; A potent vasoactive substance which is thought to play a key r [...] (151 aa)
cytochrome P450, family 11, subfamily B, polypeptide 2; Has steroid 11-beta-hydroxylase activit [...] (503 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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