KIT protein (Homo sapiens) - STRING interaction network

KIT protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K) (976 aa)
		(Homo sapiens)
Predicted Functional Partners:
	KITLG	KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of bo [...] (273 aa)	•	•	•		0.999
	GRB2	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)	•	•	•		0.999
	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) pr [...] (724 aa)	•	•	•		0.998
	PTPN6	protein tyrosine phosphatase, non-receptor type 6; Plays a key role in hematopoiesis. This PTPa [...] (624 aa)	•	•	•		0.997
	SH2B3	SH2B adaptor protein 3; Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB [...] (575 aa)	•	•	•		0.993
	EPOR	erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythrob [...] (508 aa)	•	•	•		0.992
	JAK2	Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)	•	•	•	•	0.989
	PTPN11	protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)	•	•	•		0.989
	LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Down regulates expression of stem cel [...] (512 aa)	•	•	•	•	0.984
	MATK	megakaryocyte-associated tyrosine kinase; Could play a significant role in the signal transduct [...] (508 aa)	•	•	•	•	0.984

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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