FLCN protein (Homo sapiens) - STRING interaction network

FLCN protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	FLCN	folliculin; May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways (579 aa)
		(Homo sapiens)
Predicted Functional Partners:
	FNIP1	folliculin interacting protein 1; May be involved in energy and/or nutrient sensing through the [...] (1166 aa)	•	•	0.996
	FNIP2	folliculin interacting protein 2; May be involved in energy and/or nutrient sensing through the [...] (1114 aa)		•	0.984
	PRKAA2	protein kinase, AMP-activated, alpha 2 catalytic subunit; Responsible for the regulation of fat [...] (552 aa)	•	•	0.949
	MTOR	mechanistic target of rapamycin (serine/threonine kinase); Kinase subunit of both mTORC1 and mT [...] (2549 aa)		•	0.945
	PRKAG1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit; AMPK is responsible for the regul [...] (331 aa)		•	0.843
	PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit; Responsible for the regulation of fat [...] (574 aa)		•	0.825
	PRKAB1	protein kinase, AMP-activated, beta 1 non-catalytic subunit; AMPK is responsible for the regula [...] (270 aa)		•	0.794
	PRCC	papillary renal cell carcinoma (translocation-associated) (491 aa)		•	0.776
	TSC2	tuberous sclerosis 2; In complex with TSC1, inhibits the nutrient-mediated or growth factor-sti [...] (1807 aa)		•	0.763
	FH	fumarate hydratase; Also acts as a tumor suppressor (510 aa)		•	0.760

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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