version_number_image
  APP protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
APP
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) (770 aa)
(Homo sapiens)
Predicted Functional Partners:
APBB1
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); Adapter protein that fo [...] (708 aa)
     0.999
APBA1
amyloid beta (A4) precursor protein-binding, family A, member 1; Putative function in synaptic [...] (837 aa)
      0.999
PSEN1
presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease comple [...] (467 aa)
      0.999
APBA2
amyloid beta (A4) precursor protein-binding, family A, member 2; Putative function in synaptic [...] (749 aa)
      0.999
PSEN2
presenilin 2 (Alzheimer disease 4); Probable catalytic subunit of the gamma-secretase complex, [...] (448 aa)
      0.998
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2; May modulate the internalizati [...] (736 aa)
      0.998
APOE
apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particle [...] (317 aa)
      0.998
A2M
alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping [...] (1474 aa)
     0.997
APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalizati [...] (493 aa)
      0.996
IDE
insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, IAPP, glucagon, br [...] (1019 aa)
      0.994
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (12%)
Permalink