UCHL1 protein (Homo sapiens) - STRING interaction network

UCHL1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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Your Input:
	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (223 aa)
		(Homo sapiens)
Predicted Functional Partners:
	SNCA	synuclein, alpha (non A4 component of amyloid precursor); May be involved in the regulation of [...] (140 aa)		•	•	0.994
	UBA52	ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covale [...] (128 aa)	•		•	0.986
	PTPRC	protein tyrosine phosphatase, receptor type, C; Required for T-cell activation through the anti [...] (1304 aa)			•	0.954
	USP21	ubiquitin specific peptidase 21; Deubiquitinates histone H2A, a specific tag for epigenetic tra [...] (565 aa)	•		•	0.931
	PARK2	Parkinson disease (autosomal recessive, juvenile) 2, parkin; Functions within a multiprotein E3 [...] (465 aa)			•	0.930
	KRT4	keratin 4 (594 aa)	•			0.927
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)	•		•	0.925
	PINK1	PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stre [...] (581 aa)			•	0.907
	PARK7	Parkinson disease (autosomal recessive, early onset) 7; Acts as a positive regulator of androge [...] (189 aa)			•	0.904
	LRRK2	leucine-rich repeat kinase 2; Probable protein kinase whose role is not yet known. May play a r [...] (2527 aa)			•	0.901

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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