ATM protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

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ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylate [...] (3056 aa)
(Homo sapiens)
Predicted Functional Partners:
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
CHK2 checkpoint homolog (S. pombe); Regulates cell cycle checkpoints and apoptosis in response [...] (586 aa)
MRE11 meiotic recombination 11 homolog A (S. cerevisiae); Component of the MRN complex, which p [...] (708 aa)
H2A histone family, member X; Variant histone H2A which replaces conventional H2A in a subset o [...] (143 aa)
CHK1 checkpoint homolog (S. pombe); Required for checkpoint mediated cell cycle arrest in respo [...] (476 aa)
nibrin; Component of the MRE11/RAD50/NBN (MRN complex) which plays a critical role in the cellu [...] (754 aa)
c-abl oncogene 1, receptor tyrosine kinase; Regulates cytoskeleton remodeling during cell diffe [...] (1149 aa)
RAD50 homolog (S. cerevisiae); Component of the MRN complex, which plays a central role in doub [...] (1312 aa)
tumor protein p53 binding protein 1; May have a role in checkpoint signaling during mitosis (By [...] (1977 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
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Co-expression Experiments Databases Textmining
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