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  POU2F1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
POU2F1
POU class 2 homeobox 1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes (743 aa)
(Homo sapiens)
Predicted Functional Partners:
POU2AF1
POU class 2 associating factor 1; Transcriptional coactivator that specifically associates with [...] (256 aa)
      0.999
SP1
Sp1 transcription factor; Transcription factor that can activate or repress transcription in re [...] (785 aa)
      0.992
SNAPC4
small nuclear RNA activating complex, polypeptide 4, 190kDa; Part of the SNAPc complex required [...] (1469 aa)
      0.991
HCFC1
host cell factor C1 (VP16-accessory protein); Involved in control of the cell cycle. Also antag [...] (2035 aa)
      0.983
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); Receptor for glucoco [...] (778 aa)
      0.979
SOX2
SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with O [...] (317 aa)
      0.976
TBP
TATA box binding protein; General transcription factor that functions at the core of the DNA-bi [...] (339 aa)
     0.966
GADD45A
growth arrest and DNA-damage-inducible, alpha; Binds to proliferating cell nuclear antigen. Mig [...] (165 aa)
      0.962
BRCA1
breast cancer 1, early onset; The BRCA1-BARD1 heterodimer coordinates a diverse range of cellul [...] (1863 aa)
     0.956
XRCC6
X-ray repair complementing defective repair in Chinese hamster cells 6; Single stranded DNA-dep [...] (609 aa)
       0.925
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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