ERBB2 protein (Homo sapiens) - STRING interaction network

ERBB2 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin (1255 aa)
		(Homo sapiens)
Predicted Functional Partners:
	ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by ne [...] (1342 aa)	•	•	•	•	0.999
	EGFR	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avi [...] (1210 aa)	•	•	•	•	0.999
	GRB2	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)	•	•	•		0.999
	EGF	epidermal growth factor (beta-urogastrone); EGF stimulates the growth of various epidermal and [...] (1207 aa)	•	•	•		0.999
	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)	•	•	•		0.999
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1; Signaling adapter that couples a [...] (584 aa)	•	•	•		0.998
	GRB7	growth factor receptor-bound protein 7; Interacts with the cytoplasmic domain of the epidermal [...] (532 aa)	•		•		0.997
	ESR1	estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are inv [...] (595 aa)	•		•		0.997
	ERBB2IP	erbb2 interacting protein; Acts as an adapter for the receptor ERBB2, in epithelia. By binding [...] (1371 aa)	•		•		0.997
	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone. Has ATPase a [...] (854 aa)	•		•		0.996

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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