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  ACAN protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
ACAN
aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2416 aa)
(Homo sapiens)
Predicted Functional Partners:
ADAMTS4
ADAM metallopeptidase with thrombospondin type 1 motif, 4; Cleaves aggrecan, a cartilage proteo [...] (837 aa)
      0.996
FBLN1
fibulin 1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhe [...] (703 aa)
      0.977
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5; Cleaves aggrecan, a cartilage proteo [...] (930 aa)
      0.974
TNR
tenascin R (restrictin, janusin); Neural extracellular matrix (ECM) protein involved in interac [...] (1358 aa)
      0.968
IHH
Indian hedgehog homolog (Drosophila); Intercellular signal essential for a variety of patternin [...] (411 aa)
       0.965
RUNX2
runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiat [...] (589 aa)
       0.961
COL2A1
collagen, type II, alpha 1; Type II collagen is specific for cartilaginous tissues. It is essen [...] (1487 aa)
       0.956
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
       0.954
SOX9
SRY (sex determining region Y)-box 9; Plays an important role in the normal skeletal developmen [...] (509 aa)
       0.954
IVD
isovaleryl Coenzyme A dehydrogenase (423 aa)
       0.953
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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