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  PML protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PML
promyelocytic leukemia; Probable transcription factor. May play an important role in recruitment of ELF4 into PML nuclear bodies. Inhibits specifically the activity of the tetrameric form of PKM2. May play a role in glycolytic metabolism by modulating the activity of PKM2. Together with SATB1, involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus (882 aa)
(Homo sapiens)
Predicted Functional Partners:
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
     0.999
SUMO1
SUMO1 pseudogene 3; Ubiquitin-like protein which can be covalently attached to target lysines a [...] (101 aa)
      0.999
BING2
Death domain-associated protein 6 (Daxx)(hDaxx)(Fas death domain-associated protein)(ETS1-assoc [...] (740 aa)
      0.998
RARA
retinoic acid receptor, alpha; This is a receptor for retinoic acid. Retinoic acid has profound [...] (462 aa)
     0.997
MDM2
Mdm2 p53 binding protein homolog (mouse); Inhibits TP53/p53- and TP73/p73-mediated cell cycle a [...] (497 aa)
      0.995
ZFYVE9
zinc finger, FYVE domain containing 9; Involved in recruiting unphosphorylated forms of SMAD2/S [...] (1425 aa)
     0.991
SMAD2
SMAD family member 2; Transcriptional modulator activated by TGF-beta and activin type 1 recept [...] (467 aa)
     0.986
ZBTB16
zinc finger and BTB domain containing 16; Probable transcription factor. May play a role in mye [...] (673 aa)
      0.985
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation [...] (2442 aa)
      0.977
HDAC1
histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (482 aa)
      0.969
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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