OBFC2B protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
oligonucleotide/oligosaccharide-binding fold containing 2B; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombi [...] (211 aa)
(Homo sapiens)
Predicted Functional Partners:
SOSS complex subunit C (Sensor of single-strand DNA complex subunit C)(Sensor of ssDNA subunit [...] (104 aa)
integrator complex subunit 3; Component of the Integrator complex. The Integrator complex is in [...] (1042 aa)
oligonucleotide/oligosaccharide-binding fold containing 2A; Component of the SOSS complex, a mu [...] (204 aa)
splA/ryanodine receptor domain and SOCS box containing 1; Probable substrate recognition compon [...] (273 aa)
single-stranded DNA binding protein 1; This protein binds preferentially and cooperatively to s [...] (148 aa)
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); May participate in a common DNA damage r [...] (339 aa)
ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signa [...] (3056 aa)
replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA met [...] (616 aa)
single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha [...] (388 aa)
replication protein A4, 34kDa; Absolutely required for simian virus 40 DNA replication in vitro [...] (261 aa)
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Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
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