version_number_image
  OBFC2B protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
OBFC2B
oligonucleotide/oligosaccharide-binding fold containing 2B; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombi [...] (211 aa)
(Homo sapiens)
Predicted Functional Partners:
C9orf80
SOSS complex subunit C (Sensor of single-strand DNA complex subunit C)(Sensor of ssDNA subunit [...] (104 aa)
      0.988
INTS3
integrator complex subunit 3; Component of the Integrator complex. The Integrator complex is in [...] (1042 aa)
      0.986
OBFC2A
oligonucleotide/oligosaccharide-binding fold containing 2A; Component of the SOSS complex, a mu [...] (204 aa)
    0.903
SPSB1
splA/ryanodine receptor domain and SOCS box containing 1; Probable substrate recognition compon [...] (273 aa)
       0.873
SSBP1
single-stranded DNA binding protein 1; This protein binds preferentially and cooperatively to s [...] (148 aa)
       0.858
RAD51
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae); May participate in a common DNA damage r [...] (339 aa)
      0.831
ATM
ataxia telangiectasia mutated; Serine/threonine protein kinase which activates checkpoint signa [...] (3056 aa)
      0.819
RPA1
replication protein A1, 70kDa; Plays an essential role in several cellular processes in DNA met [...] (616 aa)
       0.727
SSBP3
single stranded DNA binding protein 3; May be involved in transcription regulation of the alpha [...] (388 aa)
       0.724
RPA4
replication protein A4, 34kDa; Absolutely required for simian virus 40 DNA replication in vitro [...] (261 aa)
       0.647
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (4%)
Permalink