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  BMPR1B protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
BMPR1B
bone morphogenetic protein receptor, type IB; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1 (502 aa)
(Homo sapiens)
Predicted Functional Partners:
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induct [...] (408 aa)
     0.999
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
     0.999
BMP7
bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive f [...] (431 aa)
     0.999
BMP6
bone morphogenetic protein 6; Induces cartilage and bone formation (513 aa)
     0.999
NOG
noggin; Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogene [...] (232 aa)
      0.996
SMAD9
SMAD family member 9; Transcriptional modulator activated by BMP (bone morphogenetic proteins) [...] (467 aa)
      0.996
GDF5
growth differentiation factor 5; Could be involved in bone formation (501 aa)
      0.988
SMAD6
SMAD family member 6; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 r [...] (496 aa)
     0.987
SMAD1
SMAD family member 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) [...] (465 aa)
      0.982
SMAD5
SMAD family member 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) [...] (464 aa)
      0.981
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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