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  EPAS1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
EPAS1
endothelial PAS domain protein 1; Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcript [...] (870 aa)
(Homo sapiens)
Predicted Functional Partners:
ARNT
aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) recept [...] (789 aa)
    0.999
EGLN1
egl nine homolog 1 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (426 aa)
     0.998
VHL
von Hippel-Lindau tumor suppressor; Involved in the ubiquitination and subsequent proteasomal d [...] (213 aa)
     0.998
VEGFA
vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and [...] (412 aa)
      0.995
FLT1
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor [...] (1338 aa)
      0.985
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; [...] (402 aa)
      0.984
EP300
microRNA 1281; Functions as histone acetyltransferase and regulates transcription via chromatin [...] (2414 aa)
     0.975
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2; Specifically recognizes the xenobiotic respon [...] (717 aa)
    0.974
EGLN3
egl nine homolog 3 (C. elegans); Catalyzes the post-translational formation of 4- hydroxyprolin [...] (239 aa)
     0.970
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase); Receptor for VEGF or VEGFC [...] (1356 aa)
      0.966
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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