version_number_image
  NOTCH3 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NOTCH3
Notch homolog 3 (Drosophila); Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) (2321 aa)
(Homo sapiens)
Predicted Functional Partners:
RBPJ
recombination signal binding protein for immunoglobulin kappa J region; Transcriptional regulat [...] (500 aa)
     0.996
MAML1
mastermind-like 1 (Drosophila); Acts as a transcriptional coactivator for NOTCH proteins. Has b [...] (1016 aa)
     0.995
MAML3
mastermind-like 3 (Drosophila); Acts as a transcriptional coactivator for NOTCH proteins. Has b [...] (985 aa)
     0.990
MAML2
mastermind-like 2 (Drosophila); Acts as a transcriptional coactivator for NOTCH proteins. Has b [...] (1156 aa)
     0.984
DLL1
delta-like 1 (Drosophila); Acts as a ligand for Notch receptors. Blocks the differentiation of [...] (723 aa)
    0.984
JAG1
jagged 1 (Alagille syndrome); Ligand for multiple Notch receptors and involved in the mediation [...] (1218 aa)
    0.983
PSEN1
presenilin 1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease comple [...] (467 aa)
     0.983
LFNG
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; Glycosyltransferase that initiate [...] (379 aa)
      0.967
JAG2
jagged 2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb [...] (1238 aa)
    0.958
NRARP
NOTCH-regulated ankyrin repeat protein; May play a role in the formation of somites (By similar [...] (114 aa)
       0.957
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (8%)
Permalink