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  MAPK3 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
MAPK3
mitogen-activated protein kinase 3; Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) (379 aa)
(Homo sapiens)
Predicted Functional Partners:
ELK1
ELK1, member of ETS oncogene family; Stimulates transcription. Binds to purine-rich DNA sequenc [...] (428 aa)
     0.999
PTPN7
protein tyrosine phosphatase, non-receptor type 7; Protein phosphatase that acts preferentially [...] (399 aa)
     0.999
MAP2K1
mitogen-activated protein kinase kinase 1; Catalyzes the concomitant phosphorylation of a threo [...] (393 aa)
    0.999
DUSP1
dual specificity phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase E [...] (367 aa)
     0.999
PTPN11
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)
     0.998
MAP2K2
mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threo [...] (400 aa)
    0.998
EGF
epidermal growth factor (beta-urogastrone); EGF stimulates the growth of various epidermal and [...] (1207 aa)
      0.996
DUSP3
dual specificity phosphatase 3; This protein shows activity both toward tyrosine-protein phosph [...] (185 aa)
     0.996
DUSP6
dual specificity phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family (381 aa)
     0.996
DUSP4
dual specificity phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating bo [...] (394 aa)
     0.996
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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