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  PDGFRB protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PDGFRB
platelet-derived growth factor receptor, beta polypeptide; Receptor that binds specifically to PDGFB and PDGFD and has a tyrosine-protein kinase activity. Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2 (1106 aa)
(Homo sapiens)
Predicted Functional Partners:
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha); Binds to activated (phosphorylated) pr [...] (724 aa)
     0.999
PTPN11
protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cyt [...] (593 aa)
     0.999
RASA1
RAS p21 protein activator (GTPase activating protein) 1; Inhibitory regulator of the Ras-cyclic [...] (1047 aa)
     0.999
PDGFB
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) [...] (241 aa)
     0.999
PLCG1
phospholipase C, gamma 1; PLC-gamma is a major substrate for heparin-binding growth factor 1 (a [...] (1291 aa)
     0.999
NCK1
NCK adaptor protein 1; Adapter protein which associates with tyrosine- phosphorylated growth fa [...] (377 aa)
     0.999
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
     0.999
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; Scaffold protein tha [...] (358 aa)
     0.998
PIK3R2
phosphoinositide-3-kinase, regulatory subunit 2 (beta); Binds to activated (phosphorylated) pro [...] (728 aa)
     0.999
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
    0.997
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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