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  TRPV4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TRPV4
transient receptor potential cation channel, subfamily V, member 4; Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (871 aa)
(Homo sapiens)
Predicted Functional Partners:
MAP7
microtubule-associated protein 7; Microtubule-stabilizing protein that may play an important ro [...] (749 aa)
      0.956
AQP4
aquaporin 4; Forms a water-specific channel. Osmoreceptor which regulates body water balance an [...] (323 aa)
       0.866
FOS
FBJ murine osteosarcoma viral oncogene homolog; Nuclear phosphoprotein which forms a tight but [...] (380 aa)
       0.822
SELP
selectin P (granule membrane protein 140kDa, antigen CD62); Ca(2+)-dependent receptor for myelo [...] (830 aa)
       0.818
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
       0.816
PGR
progesterone receptor; The steroid hormones and their receptors are involved in the regulation [...] (933 aa)
       0.815
CYP2J2
cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid [...] (502 aa)
       0.813
UBE3B
ubiquitin protein ligase E3B; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ub [...] (1068 aa)
       0.809
KIF1B
kinesin family member 1B; Motor for anterograde transport of mitochondria. Has a microtubule pl [...] (1770 aa)
       0.794
TRPC1
transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor- [...] (759 aa)
       0.784
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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