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  VWF protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
VWF
von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (2813 aa)
(Homo sapiens)
Predicted Functional Partners:
GP1BA
glycoprotein Ib (platelet), alpha polypeptide; GP-Ib, a surface membrane protein of platelets, [...] (640 aa)
      0.999
F8
coagulation factor VIII, procoagulant component; Factor VIII, along with calcium and phospholip [...] (2351 aa)
      0.997
ITGA2B
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); Integrin alph [...] (1039 aa)
      0.981
COL1A2
collagen, type I, alpha 2; Type I collagen is a member of group I collagen (fibrillar forming c [...] (1366 aa)
      0.962
COL1A1
collagen, type I, alpha 1; Type I collagen is a member of group I collagen (fibrillar forming c [...] (1464 aa)
      0.962
FN1
fibronectin 1; Fibronectins bind cell surfaces and various compounds including collagen, fibrin [...] (2477 aa)
       0.954
ICAM1
intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein [...] (532 aa)
       0.954
VEGFA
vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and [...] (412 aa)
       0.954
GP6
glycoprotein VI (platelet); Collagen receptor involved in collagen-induced platelet adhesion an [...] (620 aa)
       0.951
COL3A1
collagen, type III, alpha 1; Collagen type III occurs in most soft connective tissues along wit [...] (1466 aa)
       0.951
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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