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  APC protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
APC
adenomatous polyposis coli; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state (2843 aa)
(Homo sapiens)
Predicted Functional Partners:
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa; Involved in the regulation of cell adhesi [...] (781 aa)
    0.999
AXIN1
axin 1; Controls dorsoventral patterning via two opposing effects; down-regulates beta-catenin [...] (862 aa)
     0.999
AXIN2
axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitat [...] (843 aa)
     0.996
GSK3B
glycogen synthase kinase 3 beta; Participates in the Wnt signaling pathway. Implicated in the h [...] (433 aa)
     0.996
ARHGEF4
Rho guanine nucleotide exchange factor (GEF) 4; Acts as guanine nucleotide exchange factor (GEF [...] (690 aa)
     0.989
BTRC
beta-transducin repeat containing; Substrate recognition component of a SCF (SKP1-CUL1-F- box p [...] (605 aa)
     0.988
BUB3
budding uninhibited by benzimidazoles 3 homolog (yeast); Required for kinetochore localization [...] (328 aa)
     0.988
BUB1B
budding uninhibited by benzimidazoles 1 homolog beta (yeast); Essential component of the mitoti [...] (1050 aa)
     0.987
BUB1
budding uninhibited by benzimidazoles 1 homolog (yeast); Involved in cell cycle checkpoint enfo [...] (1085 aa)
     0.987
MAPRE1
microtubule-associated protein, RP/EB family, member 1; May be involved in microtubule polymeri [...] (268 aa)
      0.985
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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