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  IPO8 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
IPO8
importin 8; Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the [...] (1037 aa)
(Homo sapiens)
Predicted Functional Partners:
EIF2C2
Protein argonaute-2 (EC 3.1.26.n1)(Argonaute2)(hAgo2)(Protein slicer)(PAZ Piwi domain protein)( [...] (859 aa)
      0.870
SRP19
signal recognition particle 19kDa; Signal-recognition-particle assembly, binds directly to 7S R [...] (144 aa)
      0.821
RANGAP1
Ran GTPase activating protein 1; GTPase activator for the nuclear Ras-related regulatory protei [...] (587 aa)
      0.810
RAN
RAN, member RAS oncogene family; GTP-binding protein involved in nucleocytoplasmic transport. R [...] (216 aa)
       0.753
KPNB1
karyopherin (importin) beta 1; Functions in nuclear protein import, either in association with [...] (876 aa)
     0.704
NUFIP2
nuclear fragile X mental retardation protein interacting protein 2; Binds RNA (695 aa)
       0.690
KPNA2
karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Functions in nuclear protein import as an [...] (529 aa)
       0.685
KDM2B
lysine (K)-specific demethylase 2B; Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' [...] (1336 aa)
       0.669
RPLP2
ribosomal protein, large, P2; Plays an important role in the elongation step of protein synthes [...] (115 aa)
       0.667
GAPDH
glyceraldehyde-3-phosphate dehydrogenase; Independent of its glycolytic activity it is also inv [...] (335 aa)
       0.631
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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