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  CYP2E1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms (493 aa)
(Homo sapiens)
Predicted Functional Partners:
ALDH2
aldehyde dehydrogenase 2 family (mitochondrial) (517 aa)
      0.997
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
      0.987
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); May have [...] (604 aa)
      0.978
ADH1A
alcohol dehydrogenase 1C (class I), gamma polypeptide (375 aa)
      0.977
GSTM1
glutathione S-transferase mu 1; Conjugation of reduced glutathione to a wide number of exogenou [...] (218 aa)
      0.977
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic); Biotransformation enzyme that catalyzes the hydro [...] (455 aa)
      0.977
GSTP1
glutathione S-transferase pi 1; Conjugation of reduced glutathione to a wide number of exogenou [...] (210 aa)
      0.977
GSTM3
glutathione S-transferase mu 3 (brain); Conjugation of reduced glutathione to a wide number of [...] (225 aa)
      0.975
GSTA4
glutathione S-transferase alpha 4; Conjugation of reduced glutathione to a wide number of exoge [...] (222 aa)
      0.975
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A1; UDPGT is of major importance in the conju [...] (533 aa)
      0.967
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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