version_number_image
  APOE protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
APOE
apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues (317 aa)
(Homo sapiens)
Predicted Functional Partners:
LDLR
low density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plas [...] (860 aa)
     0.999
LPL
lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of c [...] (475 aa)
      0.999
APP
amyloid beta (A4) precursor protein; N-APP binds TNFRSF21 triggering caspase activation and deg [...] (770 aa)
      0.998
A2MR
Prolow-density lipoprotein receptor-related protein 1 Precursor (LRP)(Alpha-2-macroglobulin rec [...] (4544 aa)
     0.997
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface rec [...] (963 aa)
      0.997
APOC2
apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, a [...] (101 aa)
      0.996
APOC3
apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake o [...] (99 aa)
      0.996
APOB
apolipoprotein B (including Ag(x) antigen); Apolipoprotein B is a major protein constituent of [...] (4563 aa)
      0.995
MAPT
microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be i [...] (776 aa)
      0.994
VLDLR
very low density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. [...] (873 aa)
      0.991
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (15%)
Permalink