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  WNK4 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
WNK4
WNK lysine deficient protein kinase 4; Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis (By similarity) (1243 aa)
(Homo sapiens)
Predicted Functional Partners:
SLC12A3
solute carrier family 12 (sodium/chloride transporters), member 3; Electrically silent transpor [...] (1030 aa)
      0.996
KCNJ1
potassium inwardly-rectifying channel, subfamily J, member 1; In the kidney, probably plays a m [...] (391 aa)
       0.992
ITSN1
intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the [...] (1721 aa)
       0.982
OSR1
odd-skipped related 1 (Drosophila) (266 aa)
       0.952
SLC12A1
solute carrier family 12 (sodium/potassium/chloride transporters), member 1; Electrically silen [...] (1099 aa)
       0.910
STK39
serine threonine kinase 39 (STE20/SPS1 homolog, yeast); May act as a mediator of stress-activat [...] (545 aa)
     0.886
CACNA2D1
calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of volta [...] (1091 aa)
       0.819
SLC12A2
solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Electrically silen [...] (1212 aa)
       0.792
CLDN4
claudin 4; Plays a major role in tight junction-specific obliteration of the intercellular spac [...] (209 aa)
      0.772
TRPV5
transient receptor potential cation channel, subfamily V, member 5; Constitutively active calci [...] (729 aa)
       0.752
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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