WNK4 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
WNK lysine deficient protein kinase 4; Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis (By similarity) (1243 aa)
(Homo sapiens)
Predicted Functional Partners:
solute carrier family 12 (sodium/chloride transporters), member 3; Electrically silent transpor [...] (1030 aa)
potassium inwardly-rectifying channel, subfamily J, member 1; In the kidney, probably plays a m [...] (391 aa)
intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the [...] (1721 aa)
odd-skipped related 1 (Drosophila) (266 aa)
solute carrier family 12 (sodium/potassium/chloride transporters), member 1; Electrically silen [...] (1099 aa)
serine threonine kinase 39 (STE20/SPS1 homolog, yeast); May act as a mediator of stress-activat [...] (545 aa)
calcium channel, voltage-dependent, alpha 2/delta subunit 1; The alpha-2/delta subunit of volta [...] (1091 aa)
solute carrier family 12 (sodium/potassium/chloride transporters), member 2; Electrically silen [...] (1212 aa)
claudin 4; Plays a major role in tight junction-specific obliteration of the intercellular spac [...] (209 aa)
transient receptor potential cation channel, subfamily V, member 5; Constitutively active calci [...] (729 aa)
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network


Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (2%)