version_number_image
  TARDBP protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TARDBP
TAR DNA binding protein; DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat (414 aa)
(Homo sapiens)
Predicted Functional Partners:
XRN2
5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote [...] (950 aa)
       0.998
EXOSC10
exosome component 10; Part of a post-splicing multiprotein complex involved in both mRNA nuclea [...] (885 aa)
       0.998
SOD1
superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells [...] (154 aa)
       0.966
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covale [...] (128 aa)
       0.965
GRN
granulin; Granulins have possible cytokine-like activity. They may play a role in inflammation, [...] (593 aa)
       0.945
VCP
valosin-containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and [...] (806 aa)
       0.917
FUS
fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independe [...] (526 aa)
       0.917
PICK1
protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcel [...] (415 aa)
       0.911
ANG
angiogenin, ribonuclease, RNase A family, 5; May function as a tRNA-specific ribonuclease that [...] (147 aa)
       0.910
TMEM106B
transmembrane protein 106B (274 aa)
       0.910
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (2%)
Permalink