TARDBP protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

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TAR DNA binding protein; DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat (414 aa)
(Homo sapiens)
Predicted Functional Partners:
5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote [...] (950 aa)
exosome component 10; Part of a post-splicing multiprotein complex involved in both mRNA nuclea [...] (885 aa)
superoxide dismutase 1, soluble; Destroys radicals which are normally produced within the cells [...] (154 aa)
ubiquitin A-52 residue ribosomal protein fusion product 1; Protein modifier which can be covale [...] (128 aa)
granulin; Granulins have possible cytokine-like activity. They may play a role in inflammation, [...] (593 aa)
valosin-containing protein; Necessary for the fragmentation of Golgi stacks during mitosis and [...] (806 aa)
fused in sarcoma; Binds both single-stranded and double-stranded DNA and promotes ATP-independe [...] (526 aa)
protein interacting with PRKCA 1; Probable adapter protein that bind to and organize the subcel [...] (415 aa)
angiogenin, ribonuclease, RNase A family, 5; May function as a tRNA-specific ribonuclease that [...] (147 aa)
transmembrane protein 106B (274 aa)
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Co-expression Experiments Databases Textmining
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