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  IL12B protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
IL12B
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the production of IFN-gamma by resting PBMC (328 aa)
(Homo sapiens)
Predicted Functional Partners:
IL12A
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation fact [...] (253 aa)
     0.999
IL23A
interleukin 23, alpha subunit p19; Associates with IL12B to form the IL-23 interleukin, an hete [...] (189 aa)
     0.999
IL12RB1
interleukin 12 receptor, beta 1; Functions as an interleukin receptor which binds interleukin-1 [...] (381 aa)
     0.999
IL12RB2
interleukin 12 receptor, beta 2; Receptor for interleukin-12. This subunit is the signaling com [...] (862 aa)
     0.998
IFNG
interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamm [...] (166 aa)
      0.996
IL6
interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is [...] (212 aa)
      0.996
IL23R
interleukin 23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL2 [...] (629 aa)
      0.996
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor); Transcription [...] (770 aa)
      0.995
IL1B
interleukin 1, beta; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation [...] (269 aa)
      0.993
STAT1
signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of t [...] (750 aa)
      0.993
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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