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  CCL2 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CCL2
chemokine (C-C motif) ligand 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (99 aa)
(Homo sapiens)
Predicted Functional Partners:
CCR2
chemokine (C-C motif) receptor 2; Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Transduce [...] (374 aa)
     0.999
CCR5
chemokine (C-C motif) receptor 5; Receptor for a number of inflammatory CC-chemokines including [...] (352 aa)
     0.998
CCR1
chemokine (C-C motif) receptor 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP- [...] (355 aa)
     0.997
IL8
interleukin 8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, [...] (99 aa)
     0.995
TNF
tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TN [...] (233 aa)
       0.993
DARC
Duffy blood group, chemokine receptor; Non-specific receptor for many chemokines such as IL-8, [...] (338 aa)
      0.990
CCR3
chemokine (C-C motif) receptor 3; Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin- [...] (355 aa)
     0.989
CX3CR1
chemokine (C-X3-C motif) receptor 1; Receptor for the CX3C chemokine fractalkine and mediates b [...] (355 aa)
      0.984
IL10
interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL- [...] (178 aa)
       0.982
MMP1
matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III [...] (469 aa)
      0.979
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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