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  GCK protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
GCK
glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (466 aa)
(Homo sapiens)
Predicted Functional Partners:
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
      0.997
GCKR
glucokinase (hexokinase 4) regulator; Inhibits glucokinase by forming an inactive complex with [...] (625 aa)
      0.996
GPI
glucose phosphate isomerase; Besides it's role as a glycolytic enzyme, mammalian GPI can functi [...] (558 aa)
      0.969
PDX1
pancreatic and duodenal homeobox 1; Activates insulin, somatostatin, glucokinase, islet amyloid [...] (283 aa)
       0.965
HNF1A
HNF1 homeobox A; Required for the expression of several liver specific genes. Binds to the inve [...] (631 aa)
       0.965
SREBF1
sterol regulatory element binding transcription factor 1; Transcriptional activator required fo [...] (1177 aa)
      0.964
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
       0.960
HNF4A
hepatocyte nuclear factor 4, alpha; Transcriptionally controlled transcription factor. Binds to [...] (474 aa)
       0.960
ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP- [...] (1581 aa)
       0.958
PKLR
pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) (574 aa)
     0.956
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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