GCK protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

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glucokinase (hexokinase 4); Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage (466 aa)
(Homo sapiens)
Predicted Functional Partners:
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
glucokinase (hexokinase 4) regulator; Inhibits glucokinase by forming an inactive complex with [...] (625 aa)
glucose phosphate isomerase; Besides it's role as a glycolytic enzyme, mammalian GPI can functi [...] (558 aa)
pancreatic and duodenal homeobox 1; Activates insulin, somatostatin, glucokinase, islet amyloid [...] (283 aa)
HNF1 homeobox A; Required for the expression of several liver specific genes. Binds to the inve [...] (631 aa)
sterol regulatory element binding transcription factor 1; Transcriptional activator required fo [...] (1177 aa)
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
hepatocyte nuclear factor 4, alpha; Transcriptionally controlled transcription factor. Binds to [...] (474 aa)
ATP-binding cassette, sub-family C (CFTR/MRP), member 8; Putative subunit of the beta-cell ATP- [...] (1581 aa)
pyruvate kinase, liver and RBC; Plays a key role in glycolysis (By similarity) (574 aa)
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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

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Co-expression Experiments Databases Textmining
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