version_number_image
  EPOR protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
EPOR
erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase (508 aa)
(Homo sapiens)
Predicted Functional Partners:
EPO
erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocy [...] (193 aa)
     0.999
JAK2
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
     0.999
PTPN6
protein tyrosine phosphatase, non-receptor type 6; Plays a key role in hematopoiesis. This PTPa [...] (624 aa)
     0.999
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
     0.999
SOCS3
suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feed [...] (225 aa)
     0.998
KITLG
KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of bo [...] (273 aa)
     0.998
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Down regulates expression of stem cel [...] (512 aa)
     0.998
CRKL
v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intrace [...] (303 aa)
     0.997
STAT5A
signal transducer and activator of transcription 5A; Carries out a dual function- signal transd [...] (794 aa)
      0.993
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; This is the receptor for stem ce [...] (976 aa)
     0.992
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (14%)
Permalink