version_number_image
  CYP24A1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CYP24A1
cytochrome P450, family 24, subfamily A, polypeptide 1; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23- hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product (514 aa)
(Homo sapiens)
Predicted Functional Partners:
VDR
vitamin D (1,25- dihydroxyvitamin D3) receptor; Nuclear hormone receptor. Transcription factor [...] (427 aa)
      0.985
PTH
parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing [...] (115 aa)
       0.951
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor (485 aa)
       0.922
CAMP
cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacte [...] (170 aa)
       0.913
NR1I2
nuclear receptor subfamily 1, group I, member 2; Nuclear receptor that binds and is activated b [...] (473 aa)
       0.910
CALCA
calcitonin-related polypeptide alpha; CGRP induces vasodilation. It dilates a variety of vessel [...] (141 aa)
       0.852
ZNF217
zinc finger protein 217; Binds to the promoters of target genes and functions as repressor. Pro [...] (1048 aa)
       0.844
TLR2
toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial l [...] (784 aa)
       0.835
TRPV6
transient receptor potential cation channel, subfamily V, member 6; Calcium selective cation ch [...] (725 aa)
       0.780
NCOA1
nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear recept [...] (1441 aa)
       0.760
 
  Views:                    
   Neighborhood  Fusion  Occurence  Coexpression  Experiments  Database  Textmining      Summary Network

 

Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
required confidence (score): interactors shown:
or custom value: or custom limit:

additional (white) nodes

 Server load: low (13%)
Permalink