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  THPO protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
THPO
thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets (353 aa)
(Homo sapiens)
Predicted Functional Partners:
MPL
myeloproliferative leukemia virus oncogene; Receptor for thrombopoietin. May represent a regula [...] (635 aa)
     0.999
EPO
erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocy [...] (193 aa)
       0.954
SH2B3
SH2B adaptor protein 3; Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB [...] (575 aa)
       0.944
KITLG
KIT ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of bo [...] (273 aa)
       0.944
CCND3
cyclin D3; Essential for the control of the cell cycle at the G1/S (start) transition. Potentia [...] (292 aa)
       0.939
HOXB4
homeobox B4; Sequence-specific transcription factor which is part of a developmental regulatory [...] (251 aa)
       0.932
USF1
upstream transcription factor 1; Transcription factor that binds to a symmetrical DNA sequence [...] (310 aa)
       0.931
EPOR
erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythrob [...] (508 aa)
       0.899
JAK2
Janus kinase 2; Plays a role in leptin signaling and control of body weight (By similarity). Ty [...] (1132 aa)
       0.895
MYB
v-myb myeloblastosis viral oncogene homolog (avian); Transcriptional activator; DNA-binding pro [...] (761 aa)
       0.892
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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