TFAP2C protein (Homo sapiens) - STRING interaction network

TFAP2C protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	TFAP2C	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma); Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (450 aa)
		(Homo sapiens)
Predicted Functional Partners:
	CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; Interferes w [...] (270 aa)	•	•	0.964
	WWOX	WW domain containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and pl [...] (414 aa)		•	0.937
	CITED4	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4; Acts as tran [...] (184 aa)	•	•	0.887
	GPER	G protein-coupled estrogen receptor 1; Receptor for estrogen (375 aa)		•	0.885
	AP2B1	adaptor-related protein complex 2, beta 1 subunit; Component of the adaptor protein complex 2 ( [...] (951 aa)		•	0.873
	AP2A1	adaptor-related protein complex 2, alpha 1 subunit; Component of the adaptor protein complex 2 [...] (977 aa)		•	0.748
	TP53	tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)	•	•	0.735
	FAM48A	family with sequence similarity 48, member A; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK [...] (779 aa)		•	0.714
	ZNF559	zinc finger protein 559; May be involved in transcriptional regulation (538 aa)		•	0.698
	ZFP36L1	zinc finger protein 36, C3H type-like 1; Probable regulatory protein involved in regulating the [...] (338 aa)		•	0.681

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Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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