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  CRY1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
CRY1
cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL (By similarity) (586 aa)
(Homo sapiens)
Predicted Functional Partners:
PER2
period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential fo [...] (1255 aa)
     0.999
ARNTL
aryl hydrocarbon receptor nuclear translocator-like; ARNTL-CLOCK heterodimers activate E-box el [...] (625 aa)
     0.999
PER1
period homolog 1 (Drosophila); Component of the circadian clock mechanism which is essential fo [...] (1290 aa)
     0.999
CLOCK
clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transc [...] (846 aa)
     0.998
PER3
period homolog 3 (Drosophila); Component of the circadian clock mechanism which is essential fo [...] (1201 aa)
     0.997
NPAS2
neuronal PAS domain protein 2; BMAL1-NPAS2 heterodimers activate E-box element (3'- CACGTG-5') [...] (824 aa)
     0.994
CSNK1E
casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utiliz [...] (416 aa)
     0.982
BHLHE41
basic helix-loop-helix family, member e41; May be a transcriptional repressor that represses bo [...] (482 aa)
       0.970
RORA
RAR-related orphan receptor A; Orphan nuclear receptor. Binds DNA as a monomer to hormone respo [...] (556 aa)
       0.957
NR1D1
nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional re [...] (614 aa)
       0.955
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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