Casp3 protein (Mus musculus) - STRING interaction network

Casp3 protein (Mus musculus) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	Casp3	caspase 3 Gene; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (277 aa)
		(Mus musculus)
Predicted Functional Partners:
	Apaf1	apoptotic peptidase activating factor 1 Gene; Oligomeric Apaf-1 mediates the cytochrome c-depen [...] (1249 aa)	•	•	•	•	0.997
	Xiap	X-linked inhibitor of apoptosis Gene; Apoptotic suppressor. Has E3 ubiquitin-protein ligase act [...] (496 aa)		•	•	•	0.997
	Dffa	DNA fragmentation factor, alpha subunit Gene; Inhibitor of the caspase-activated DNase (DFF40) (331 aa)		•	•	•	0.988
	Bcl2l11	BCL2-like 11 (apoptosis facilitator) Gene; Induces apoptosis. The isoforms vary in cytotoxicity [...] (196 aa)			•	•	0.983
	Diablo	diablo homolog (Drosophila) Gene; Promotes apoptosis by activating caspases in the cytochrome c [...] (237 aa)			•	•	0.981
	Gsn	gelsolin Gene; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) e [...] (780 aa)			•	•	0.974
	Tnf	tumor necrosis factor Gene; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mai [...] (235 aa)		•		•	0.971
	Bax	BCL2-associated X protein Gene; Accelerates programmed cell death by binding to, and antagonizi [...] (192 aa)				•	0.971
	Bcl2	B-cell leukemia/lymphoma 2 Gene; Suppresses apoptosis in a variety of cell systems including fa [...] (236 aa)		•		•	0.968
	Fasl	Fas ligand (TNF superfamily, member 6) Gene; Cytokine that binds to TNFRSF6/FAS, a receptor tha [...] (279 aa)				•	0.964

Views:

Info & Parameters ...

Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

required confidence (score):

interactors shown:

or custom value:

or custom limit:

additional (white) nodes

Server load: low (37%)

Permalink