TEK protein (Homo sapiens) - STRING interaction network

TEK protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




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	TEK	TEK tyrosine kinase, endothelial; This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation (1124 aa)
		(Homo sapiens)
Predicted Functional Partners:
	ANGPT1	angiopoietin 1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Imp [...] (498 aa)	•	•	•	0.999
	ANGPT2	angiopoietin 2; Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counter [...] (496 aa)	•	•	•	0.999
	ANGPT4	angiopoietin 4; Binds to tyrosine-protein kinase receptor TIE2 and activates it (503 aa)	•	•	•	0.996
	GRB7	growth factor receptor-bound protein 7; Interacts with the cytoplasmic domain of the epidermal [...] (532 aa)	•	•	•	0.994
	GRB2	growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)	•	•	•	0.992
	ELF2	E74-like factor 2 (ets domain transcription factor); Isoform 1 transcriptionally activates the [...] (581 aa)		•	•	0.989
	DOK2	docking protein 2, 56kDa; DOK proteins are enzymatically inert adaptor or scaffolding proteins. [...] (412 aa)	•	•	•	0.983
	GRB14	growth factor receptor-bound protein 14; Interacts with the cytoplasmic domain of the autophosp [...] (540 aa)	•	•	•	0.983
	SHC1	SHC (Src homology 2 domain containing) transforming protein 1; Signaling adapter that couples a [...] (584 aa)	•	•	•	0.980
	TNIP2	TNFAIP3 interacting protein 2; Inhibits NF-kappa-B activation by blocking the interaction of RI [...] (429 aa)	•	•	•	0.974

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Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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