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  PDX1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PDX1
pancreatic and duodenal homeobox 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell (283 aa)
(Homo sapiens)
Predicted Functional Partners:
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2; Facilitative glucose trans [...] (524 aa)
      0.995
NEUROD1
neurogenic differentiation 1; Differentiation factor required for dendrite morphogenesis and ma [...] (356 aa)
      0.994
GCG
glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity [...] (180 aa)
       0.993
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
       0.993
MAFA
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian); Acts as a transcriptional fac [...] (353 aa)
      0.992
HNF4A
hepatocyte nuclear factor 4, alpha; Transcriptionally controlled transcription factor. Binds to [...] (474 aa)
       0.992
ONECUT1
one cut homeobox 1; Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' [...] (465 aa)
       0.992
PTF1A
pancreas specific transcription factor, 1a; Transcriptional activator. Binds to the E-box conse [...] (328 aa)
       0.991
HNF1B
HNF1 homeobox B; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTA [...] (557 aa)
       0.991
FOXA2
forkhead box A2; Transcription activator for a number of liver genes such as AFP, albumin, tyro [...] (463 aa)
       0.990
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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