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  PTEN protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PTEN
phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3- phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] (403 aa)
(Homo sapiens)
Predicted Functional Partners:
TP53
tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apo [...] (393 aa)
     0.999
PTK2
PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase implicated in signaling pa [...] (1052 aa)
     0.998
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2; Seems to act as scaffold [...] (1455 aa)
     0.998
PIK3CA
phosphoinositide-3-kinase, catalytic, alpha polypeptide; Phosphorylates PtdIns, PtdIns4P and Pt [...] (1068 aa)
     0.998
AKT1
v-akt murine thymoma viral oncogene homolog 1; General protein kinase capable of phosphorylatin [...] (480 aa)
     0.997
SLC9A3R1
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1; Scaffold protein tha [...] (358 aa)
     0.996
MTOR
mechanistic target of rapamycin (serine/threonine kinase); Kinase subunit of both mTORC1 and mT [...] (2549 aa)
      0.995
SLC9A3R2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2; Scaffold protein tha [...] (337 aa)
     0.994
PIK3CG
phosphoinositide-3-kinase, catalytic, gamma polypeptide; 3-phosphorylates the cellular phosphoi [...] (1102 aa)
      0.992
MAGI3
membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding pro [...] (1481 aa)
     0.992
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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