NTRK1 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.

Your Input:
neurotrophic tyrosine kinase, receptor, type 1; Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway (796 aa)
(Homo sapiens)
Predicted Functional Partners:
nerve growth factor (beta polypeptide); Nerve growth factor is important for the development an [...] (241 aa)
SHC (Src homology 2 domain containing) transforming protein 1; Signaling adapter that couples a [...] (584 aa)
nerve growth factor receptor (TNFR superfamily, member 16); Low affinity receptor which can bin [...] (427 aa)
neurotrophin 3; Seems to promotes the survival of visceral and proprioceptive sensory neurons (270 aa)
phospholipase C, gamma 1; PLC-gamma is a major substrate for heparin-binding growth factor 1 (a [...] (1291 aa)
brain-derived neurotrophic factor; During development, promotes the survival and differentiatio [...] (329 aa)
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
fibroblast growth factor receptor substrate 2; Adapter protein that links FGR and NGF receptors [...] (508 aa)
melanoma antigen family D, 1; Involved in the apoptotic response after nerve growth factor (NGF [...] (834 aa)
neurotrophin 4; Target-derived survival factor for peripheral sensory sympathetic neurons (210 aa)
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Co-expression Experiments Databases Textmining
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