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  NTRK1 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
NTRK1
neurotrophic tyrosine kinase, receptor, type 1; Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain- derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway (796 aa)
(Homo sapiens)
Predicted Functional Partners:
NGF
nerve growth factor (beta polypeptide); Nerve growth factor is important for the development an [...] (241 aa)
     0.999
SHC1
SHC (Src homology 2 domain containing) transforming protein 1; Signaling adapter that couples a [...] (584 aa)
     0.999
NGFR
nerve growth factor receptor (TNFR superfamily, member 16); Low affinity receptor which can bin [...] (427 aa)
     0.999
NTF3
neurotrophin 3; Seems to promotes the survival of visceral and proprioceptive sensory neurons (270 aa)
     0.999
PLCG1
phospholipase C, gamma 1; PLC-gamma is a major substrate for heparin-binding growth factor 1 (a [...] (1291 aa)
     0.998
BDNF
brain-derived neurotrophic factor; During development, promotes the survival and differentiatio [...] (329 aa)
      0.998
GRB2
growth factor receptor-bound protein 2; Adapter protein that provides a critical link between c [...] (217 aa)
     0.998
FRS2
fibroblast growth factor receptor substrate 2; Adapter protein that links FGR and NGF receptors [...] (508 aa)
     0.995
MAGED1
melanoma antigen family D, 1; Involved in the apoptotic response after nerve growth factor (NGF [...] (834 aa)
      0.994
NTF4
neurotrophin 4; Target-derived survival factor for peripheral sensory sympathetic neurons (210 aa)
      0.993
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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