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  PPARG protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
PPARG
peroxisome proliferator-activated receptor gamma; Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis (505 aa)
(Homo sapiens)
Predicted Functional Partners:
RXRA
retinoid X receptor, alpha; Nuclear hormone receptor. Involved in the retinoic acid response pa [...] (462 aa)
    0.999
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; Transcriptional coactiva [...] (798 aa)
      0.999
NCOA1
nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear recept [...] (1441 aa)
      0.997
NR0B2
nuclear receptor subfamily 0, group B, member 2; Acts as a negative regulator of receptor-depen [...] (257 aa)
     0.997
HDAC3
histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal p [...] (428 aa)
     0.997
MED1
mediator complex subunit 1; Component of the Mediator complex, a coactivator involved in the re [...] (1581 aa)
      0.996
INS
insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monos [...] (200 aa)
       0.994
NCOR2
nuclear receptor co-repressor 2; Mediates the transcriptional repression activity of some nucle [...] (2521 aa)
      0.993
PAX8
paired box 8; Transcription factor for the thyroid-specific expression of the genes exclusively [...] (450 aa)
      0.992
ADIPOQ
adiponectin, C1Q and collagen domain containing; Important adipokine involved in the control of [...] (244 aa)
       0.992
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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additional (white) nodes

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