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  FCGR2A protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
FCGR2A
Fc fragment of IgG, low affinity IIa, receptor (CD32); Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis (317 aa)
(Homo sapiens)
Predicted Functional Partners:
SYK
spleen tyrosine kinase; Positive effector of BCR-stimulated responses. Couples the B-cell antig [...] (635 aa)
     0.998
LYN
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog; Down regulates expression of stem cel [...] (512 aa)
    0.997
CRP
C-reactive protein, pentraxin-related; Displays several functions associated with host defense- [...] (224 aa)
      0.996
APCS
amyloid P component, serum; Can interact with DNA and histones and may scavenge nuclear materia [...] (223 aa)
      0.969
HCK
hemopoietic cell kinase; May serve as part of a signaling pathway coupling the Fc receptor to t [...] (526 aa)
    0.966
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (536 aa)
      0.966
INPP5D
inositol polyphosphate-5-phosphatase, 145kDa; Phosphatidylinositol (PtdIns) phosphatase that sp [...] (1189 aa)
       0.951
FYN
FYN oncogene related to SRC, FGR, YES; Implicated in the control of cell growth. Plays a role i [...] (537 aa)
      0.947
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; Associates with a variety [...] (86 aa)
      0.935
PTPN6
protein tyrosine phosphatase, non-receptor type 6; Plays a key role in hematopoiesis. This PTPa [...] (624 aa)
       0.927
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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