TIMP3 protein (Homo sapiens) - STRING interaction network

TIMP3 protein (Homo sapiens) - STRING interaction network

This is the evidence view. Different line colors represent the types of evidence for the association.




confidence	evidence	actions	interactive	advanced	more	less	save

Your Input:
	TIMP3	TIMP metallopeptidase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. May form part of a tissue- specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (211 aa)
		(Homo sapiens)
Predicted Functional Partners:
	ADAM17	ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its matur [...] (824 aa)	•	•	0.994
	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); In addit [...] (660 aa)	•	•	0.989
	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play [...] (707 aa)	•	•	0.979
	TNF	tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TN [...] (233 aa)		•	0.952
	MMP14	matrix metallopeptidase 14 (membrane-inserted); Seems to specifically activate progelatinase A. [...] (582 aa)	•	•	0.949
	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gel [...] (477 aa)	•	•	0.933
	MMP13	matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin o [...] (471 aa)	•	•	0.933
	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase); Receptor for VEGF or VEGFC [...] (1356 aa)	•	•	0.919
	EFEMP1	EGF-containing fibulin-like extracellular matrix protein 1 (493 aa)	•	•	0.881
	ANXA1	annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved [...] (346 aa)		•	0.865

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Active Prediction Methods:

Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining

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