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  TIMP3 protein (Homo sapiens) - STRING interaction network
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
Your Input:
TIMP3
TIMP metallopeptidase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. May form part of a tissue- specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15 (211 aa)
(Homo sapiens)
Predicted Functional Partners:
ADAM17
ADAM metallopeptidase domain 17; Cleaves the membrane-bound precursor of TNF-alpha to its matur [...] (824 aa)
      0.994
MMP2
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); In addit [...] (660 aa)
      0.989
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play [...] (707 aa)
      0.979
TNF
tumor necrosis factor (TNF superfamily, member 2); Cytokine that binds to TNFRSF1A/TNFR1 and TN [...] (233 aa)
       0.952
MMP14
matrix metallopeptidase 14 (membrane-inserted); Seems to specifically activate progelatinase A. [...] (582 aa)
      0.949
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gel [...] (477 aa)
      0.933
MMP13
matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin o [...] (471 aa)
      0.933
KDR
kinase insert domain receptor (a type III receptor tyrosine kinase); Receptor for VEGF or VEGFC [...] (1356 aa)
      0.919
EFEMP1
EGF-containing fibulin-like extracellular matrix protein 1 (493 aa)
      0.881
ANXA1
annexin A1; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved [...] (346 aa)
       0.865
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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