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  STRING: functional protein association networks
 

This is the evidence view. Different line colors represent the types of evidence for the association.

 
   
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FGFR3
fibroblast growth factor receptor 3; Receptor for acidic and basic fibroblast growth factors. Preferentially binds FGF1 (806 aa)
IGF1R
insulin-like growth factor 1 receptor; This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed-12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR is [...] (1367 aa)
FGFR4
fibroblast growth factor receptor 4; Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19 (802 aa)
KL
klotho; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity) (1012 aa)
FGFR1
fibroblast growth factor receptor 1; Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL (By similarity). A shorter form of the receptor could be a receptor for FGF1 (aFGF) (822 aa)
FGFR2
fibroblast growth factor receptor 2; Receptor for acidic and basic fibroblast growth factors (822 aa)
(Homo sapiens)
Predicted Functional Partners:
 
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Info & Parameters ...
Network Display - Nodes are either colored (if they are directly linked to the input - as in the table) or white (nodes of a higher iteration/depth). Edges, i.e. predicted functional links, consist of up to eight lines: one color for each type of evidence. Hover or click to reveal more information about the node/edge.

Active Prediction Methods:
Neighborhood Gene Fusion Co-occurrence
Co-expression Experiments Databases Textmining
 
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