kelch-like ECH-associated protein 1; Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (624 aa)

centrin, EF-hand protein, 3 (CDC31 homolog, yeast); Plays a fundamental role in microtubule-organizing center structure and function (167 aa)

spindle assembly 6 homolog (C. elegans); Required for centrosome duplication. Overexpression results in excess foci-bearing centriolar markers (657 aa)

centrosomal protein 250kDa; Probably plays an important role in centrosome cohesion during interphase (2442 aa)

tumor protein p73; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (636 aa)